This is the first time since 1987 that two teams are favored by 20 or more points in the same week.
Read and React: Cowboys and Patriots are historical favorites
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| Kansas City Chiefs vs Baltimore Ravens | |
| Type: Point Spread – Status: OPEN | |
| Baltimore Ravens | -105 |
| Kansas City Chiefs | -115 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -135 |
| Green Bay Packers | +115 |
| Cleveland Browns vs Dallas Cowboys | |
| Type: Moneyline – Status: OPEN | |
| Dallas Cowboys | -125 |
| Cleveland Browns | +105 |
| San Francisco 49ers vs New York Jets | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |