The Patriots are sporting a new look on defense and an attitude of leaving behind their lack of defense in the Super Bowl. Former defensive coordinator Matt Patricia is now head coach in Detroit. Longtime assistant Brian Flores is running the defense in New England without the formal title of coordinator
Patriots sport new-look defense after Super Bowl loss
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| Kansas City Chiefs vs Baltimore Ravens | |
| Type: Point Spread – Status: OPEN | |
| Baltimore Ravens | +100 |
| Kansas City Chiefs | -120 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -135 |
| Green Bay Packers | +115 |
| Cleveland Browns vs Dallas Cowboys | |
| Type: Moneyline – Status: OPEN | |
| Dallas Cowboys | -125 |
| Cleveland Browns | +105 |
| San Francisco 49ers vs New York Jets | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Miami Dolphins vs Buffalo Bills | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Kansas City Chiefs vs Cincinnati Bengals | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Minnesota Vikings vs New York Jets | |
| Type: Moneyline – Status: OPEN | |
| New York Jets | -180 |
| Minnesota Vikings | +155 |
| Chicago Bears vs Jacksonville Jaguars | |
| Type: Moneyline – Status: OPEN | |
| Jacksonville Jaguars | -115 |
| Chicago Bears | -105 |
| Jacksonville Jaguars vs New England Patriots | |
| Type: Moneyline – Status: OPEN | |
| New England Patriots | +250 |
| Jacksonville Jaguars | -300 |
| Carolina Panthers vs New York Giants | |
| Type: Moneyline – Status: OPEN | |
| New York Giants | -125 |
| Carolina Panthers | +105 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |