Key additions: QB Nick Foles, Edge Josh Allen, OT Jawaan Taylor Key losses: DT Malik Jackson, S Tashaun Gipson The Jacksonville Jaguars crashed and burned with Blake Bortles back at the helm in 2018—to the surprise of only their own front office. The defense cratered from its elite 2017 level, and their
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| Kansas City Chiefs vs Baltimore Ravens | |
| Type: Point Spread – Status: OPEN | |
| Baltimore Ravens | +100 |
| Kansas City Chiefs | -120 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -130 |
| Green Bay Packers | +110 |
| Chicago Bears vs Tennessee Titans | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Atlanta Falcons vs Pittsburgh Steelers | |
| Type: Point Spread – Status: OPEN | |
| Pittsburgh Steelers | -110 |
| Atlanta Falcons | -110 |
| Cincinnati Bengals vs New England Patriots | |
| Type: Total – Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Buffalo Bills vs Arizona Cardinals | |
| Type: Total – Status: OPEN | |
| Over | -105 |
| Under | -115 |
| New Orleans Saints vs Carolina Panthers | |
| Type: Total – Status: OPEN | |
| Over | -105 |
| Under | -115 |
| New York Giants vs Minnesota Vikings | |
| Type: Point Spread – Status: OPEN | |
| Minnesota Vikings | -105 |
| New York Giants | -115 |
| Miami Dolphins vs Jacksonville Jaguars | |
| Type: Moneyline – Status: OPEN | |
| Jacksonville Jaguars | +160 |
| Miami Dolphins | -185 |
| Indianapolis Colts vs Houston Texans | |
| Type: Point Spread – Status: OPEN | |
| Indianapolis Colts | -110 |
| Houston Texans | -110 |
| Los Angeles Chargers vs Las Vegas Raiders | |
| Type: Total – Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Seattle Seahawks vs Denver Broncos | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Cleveland Browns vs Dallas Cowboys | |
| Type: Total – Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Tampa Bay Buccaneers vs Washington Commanders | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Detroit Lions vs Los Angeles Rams | |
| Type: Moneyline – Status: OPEN | |
| Los Angeles Rams | +165 |
| Detroit Lions | -195 |
| San Francisco 49ers vs New York Jets | |
| Type: Moneyline – Status: OPEN | |
| San Francisco 49ers | -250 |
| New York Jets | +210 |
| Miami Dolphins vs Buffalo Bills | |
| Type: Moneyline – Status: OPEN | |
| Buffalo Bills | -105 |
| Miami Dolphins | -115 |
| Kansas City Chiefs vs Cincinnati Bengals | |
| Type: Moneyline – Status: OPEN | |
| Kansas City Chiefs | -195 |
| Cincinnati Bengals | +165 |
| Philadelphia Eagles vs Atlanta Falcons | |
| Type: Point Spread – Status: OPEN | |
| Atlanta Falcons | -115 |
| Philadelphia Eagles | -105 |
| Minnesota Vikings vs New York Jets | |
| Type: Point Spread – Status: OPEN | |
| New York Jets | -115 |
| Minnesota Vikings | -105 |
| Chicago Bears vs Jacksonville Jaguars | |
| Type: Point Spread – Status: OPEN | |
| Chicago Bears | -110 |
| Jacksonville Jaguars | -110 |
| Jacksonville Jaguars vs New England Patriots | |
| Type: Point Spread – Status: OPEN | |
| Jacksonville Jaguars | -110 |
| New England Patriots | -110 |
| Carolina Panthers vs New York Giants | |
| Type: Point Spread – Status: OPEN | |
| Carolina Panthers | -110 |
| New York Giants | -110 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |