The universal preseason favorite has been dethroned as the No. 1 Super Bowl favorite, with the Pittsburgh Steelers jumping the New England Patriots for the top spot. New England is one dominant performance away from retaking favorite bragging rights, but the Steelers bounced back from a brutal Week 3
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| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -120 |
| Green Bay Packers | +100 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |