Kansas City left-hander Jason Vargas opposes Cleveland right-hander Danny Salazar at Progressive Field.
Watch live: Royals at Indians
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| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Total – Status: OPEN | |
| Over – 1I | +225 |
| Under – 1I | -340 |
| Minnesota Twins vs Seattle Mariners | |
| Type: Moneyline – Status: OPEN | |
| Seattle Mariners | +107 |
| Minnesota Twins | -128 |
| Colorado Rockies vs San Francisco Giants | |
| Type: Total – Status: OPEN | |
| Over – 1I | +200 |
| Under – 1I | -290 |
| New York Yankees vs Houston Astros | |
| Type: Moneyline – Status: OPEN | |
| New York Yankees – 1I | -135 |
| Houston Astros – 1I | +105 |
| Milwaukee Brewers vs St. Louis Cardinals | |
| Type: Moneyline – Status: OPEN | |
| Milwaukee Brewers – 1H | +110 |
| St. Louis Cardinals – 1H | -145 |
| Chicago White Sox vs Cleveland Guardians | |
| Type: Runline – Status: OPEN | |
| Chicago White Sox | -120 |
| Cleveland Guardians | +100 |
| Los Angeles Angels vs Kansas City Royals | |
| Type: Total – Status: OPEN | |
| Over – 1I | +230 |
| Under – 1I | -330 |