Chris Sale, who has gone 3-0 with a 2.52 ERA since rejoining the rotation, became the 10th player for the Red Sox to test positive for COVID-19 since Aug. 27.
Contending Sox dealt blow as Sale tests positive
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| Hiroshima Toyo Carp vs Hanshin Tigers | |
| Type: Total – Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Yomiuri Giants vs Tokyo Yakult Swallows | |
| Type: Runline – Status: OPEN | |
| Yomiuri Giants | +135 |
| Tokyo Yakult Swallows | -175 |
| Chunichi Dragons vs Yokohama DeNa BayStars | |
| Type: Runline – Status: OPEN | |
| Chunichi Dragons | +190 |
| Yokohama DeNa BayStars | -260 |
| Fukuoka SoftBank Hawks vs Tohoku Rakuten Golden Eagles | |
| Type: Moneyline – Status: OPEN | |
| Tohoku Rakuten Golden Eagles | +125 |
| Fukuoka SoftBank Hawks | -165 |
| Orix Buffaloes vs Chiba Lotte Marines | |
| Type: Total – Status: OPEN | |
| Over | -125 |
| Under | -105 |
| Saitama Seibu Lions vs Hokkaido Nippon-Ham Fighters | |
| Type: Runline – Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | -275 |
| Saitama Seibu Lions | +200 |
| Hanwha Eagles vs SSG Landers | |
| Type: Total – Status: OPEN | |
| Over | -115 |
| Under | -115 |
| Doosan Bears vs Samsung Lions | |
| Type: Runline – Status: OPEN | |
| Samsung Lions | +130 |
| Doosan Bears | -170 |
| Kia Tigers vs KT Wiz | |
| Type: Runline – Status: OPEN | |
| KT Wiz | -220 |
| Kia Tigers | +165 |
| Lotte Giants vs Kiwoom Heroes | |
| Type: Runline – Status: OPEN | |
| Kiwoom Heroes | +105 |
| Lotte Giants | -135 |
| NC Dinos vs LG Twins | |
| Type: Runline – Status: OPEN | |
| LG Twins | -110 |
| NC Dinos | -120 |
| TSG Hawks vs Uni-Lions | |
| Type: Moneyline – Status: OPEN | |
| Uni-Lions | -150 |
| TSG Hawks | +115 |
| Detroit Tigers vs St. Louis Cardinals | |
| Type: Moneyline – Status: OPEN | |
| St. Louis Cardinals | +105 |
| Detroit Tigers | -125 |
| Baltimore Orioles vs New York Yankees | |
| Type: Moneyline – Status: OPEN | |
| New York Yankees | -128 |
| Baltimore Orioles | +107 |
| Miami Marlins vs Colorado Rockies | |
| Type: Moneyline – Status: OPEN | |
| Colorado Rockies | +119 |
| Miami Marlins | -142 |
| Toronto Blue Jays vs Kansas City Royals | |
| Type: Total – Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Boston Red Sox vs San Francisco Giants | |
| Type: Runline – Status: OPEN | |
| San Francisco Giants | +125 |
| Boston Red Sox | -145 |
| New York Mets vs Chicago Cubs | |
| Type: Moneyline – Status: OPEN | |
| Chicago Cubs – 1I | +105 |
| New York Mets – 1I | -135 |
| Chicago White Sox vs Minnesota Twins | |
| Type: Moneyline – Status: OPEN | |
| Minnesota Twins – 1H | -180 |
| Chicago White Sox – 1H | +135 |
| Milwaukee Brewers vs Tampa Bay Rays | |
| Type: Moneyline – Status: OPEN | |
| Tampa Bay Rays | +122 |
| Milwaukee Brewers | -145 |
| Texas Rangers vs Washington Nationals | |
| Type: Runline – Status: OPEN | |
| Washington Nationals | -160 |
| Texas Rangers | +135 |
| Houston Astros vs Cleveland Guardians | |
| Type: Total – Status: OPEN | |
| Over – 1H | +100 |
| Under – 1H | -130 |
| Los Angeles Angels vs Philadelphia Phillies | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Phillies | -139 |
| Los Angeles Angels | +116 |
| Oakland Athletics vs Pittsburgh Pirates | |
| Type: Total – Status: OPEN | |
| Over – 1H | -110 |
| Under – 1H | -120 |
| Seattle Mariners vs Atlanta Braves | |
| Type: Moneyline – Status: OPEN | |
| Atlanta Braves – 1H | -120 |
| Seattle Mariners – 1H | -110 |
| Arizona Diamondbacks vs Los Angeles Dodgers | |
| Type: Moneyline – Status: OPEN | |
| Los Angeles Dodgers | -115 |
| Arizona Diamondbacks | -105 |
| San Diego Padres vs Cincinnati Reds | |
| Type: Total – Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Hiroshima Toyo Carp vs Hanshin Tigers | |
| Type: Moneyline – Status: SUSPENDED | |
| Hanshin Tigers | |
| Hiroshima Toyo Carp | |
| Fukuoka SoftBank Hawks vs Tohoku Rakuten Golden Eagles | |
| Type: Runline – Status: SUSPENDED | |
| Tohoku Rakuten Golden Eagles | |
| Fukuoka SoftBank Hawks | |
| Orix Buffaloes vs Chiba Lotte Marines | |
| Type: Moneyline – Status: SUSPENDED | |
| Chiba Lotte Marines | |
| Orix Buffaloes | |
| Saitama Seibu Lions vs Hokkaido Nippon-Ham Fighters | |
| Type: Runline – Status: SUSPENDED | |
| Hokkaido Nippon-Ham Fighters | |
| Saitama Seibu Lions | |