The Yankees and Red Sox will not open the second half of the 2021 MLB season as expected as New York is dealing with COVID-19 issues.
Red Sox-Yankees ppd. over COVID-19 issues
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| Philadelphia Phillies vs San Francisco Giants | |
| Type: Runline – Status: OPEN | |
| Philadelphia Phillies | +100 |
| San Francisco Giants | -120 |
| Cleveland Guardians vs Detroit Tigers | |
| Type: Total – Status: OPEN | |
| Over – 1H | -105 |
| Under – 1H | -125 |
| Pittsburgh Pirates vs Los Angeles Angels | |
| Type: Moneyline – Status: OPEN | |
| Los Angeles Angels – 1H | +120 |
| Pittsburgh Pirates – 1H | -160 |
| Tampa Bay Rays vs Chicago White Sox | |
| Type: Runline – Status: OPEN | |
| Chicago White Sox | -150 |
| Tampa Bay Rays | +130 |
| Minnesota Twins vs Seattle Mariners | |
| Type: Total – Status: OPEN | |
| Over – 1H | -110 |
| Under – 1H | -120 |
| Chicago Cubs vs San Diego Padres | |
| Type: Moneyline – Status: OPEN | |
| Chicago Cubs | -120 |
| San Diego Padres | +100 |
| Kansas City Royals vs Milwaukee Brewers | |
| Type: Runline – Status: OPEN | |
| Milwaukee Brewers | -175 |
| Kansas City Royals | +150 |
| St. Louis Cardinals vs New York Mets | |
| Type: Moneyline – Status: OPEN | |
| New York Mets – 1H | -105 |
| St. Louis Cardinals – 1H | -125 |
| Oakland Athletics vs Texas Rangers | |
| Type: Total – Status: OPEN | |
| Under – 1H | -110 |
| Over – 1H | -120 |
| Los Angeles Dodgers vs Miami Marlins | |
| Type: Total – Status: OPEN | |
| Under – 1I | -275 |
| Over – 1I | +190 |