The San Diego Chargers figured the formula for turning their season around included holding onto the ball and getting a tide-turning takeaway on special teams. They did all that and much more in handing the Denver Broncos their worst home loss since 1966 with a 41-3 drubbing fueled by reigning MVP LaDainian Tomlinson and his trusty backup, Michael Turner.
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| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -120 |
| Green Bay Packers | +100 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |