Here are some of the players Indianapolis Colts coach Frank Reich will have to pay special attention to in his first season. IndyStar will breakdown each of the Indianapolis Colts’ 13 opponents for the 2018 season ahead of the team reporting to camp at Grand Park on July 25. Buffalo Bills Game:Â
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| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -120 |
| Green Bay Packers | +100 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |