The Eagles will open their first Super Bowl defense when they host the Falcons to start the 2018 NFL regular season, a source confirmed to ESPN.
Source: Eagles to kick off 2018 vs. Falcons
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| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -120 |
| Green Bay Packers | +100 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |