Draft misses and a lack of QB pressure and run stopping have made the Lions defense porous and ineffective.
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| Tampa Bay Buccaneers vs Dallas Cowboys | |
| Type: Moneyline - Status: OPEN | |
| Dallas Cowboys - 4Q | |
| Tampa Bay Buccaneers - 4Q | |
| Detroit Lions vs San Francisco 49ers | |
| Type: Point Spread - Status: OPEN | |
| San Francisco 49ers | -110 |
| Detroit Lions | -110 |
| Buffalo Bills vs Pittsburgh Steelers | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Atlanta Falcons vs Philadelphia Eagles | |
| Type: Point Spread - Status: OPEN | |
| Philadelphia Eagles | -110 |
| Atlanta Falcons | -110 |
| Houston Texans vs Jacksonville Jaguars | |
| Type: Point Spread - Status: OPEN | |
| Jacksonville Jaguars | +100 |
| Houston Texans | -120 |
| Cincinnati Bengals vs Minnesota Vikings | |
| Type: Point Spread - Status: OPEN | |
| Minnesota Vikings | -115 |
| Cincinnati Bengals | -105 |
| Carolina Panthers vs New York Jets | |
| Type: Point Spread - Status: OPEN | |
| New York Jets | -110 |
| Carolina Panthers | -110 |
| Tennessee Titans vs Arizona Cardinals | |
| Type: Moneyline - Status: OPEN | |
| Arizona Cardinals | +115 |
| Tennessee Titans | -135 |
| New York Giants vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Denver Broncos | -115 |
| New York Giants | -105 |
| Indianapolis Colts vs Seattle Seahawks | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Washington Football Team vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Los Angeles Chargers | -110 |
| Washington Football Team | -110 |
| Kansas City Chiefs vs Cleveland Browns | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| New England Patriots vs Miami Dolphins | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Los Angeles Rams vs Chicago Bears | |
| Type: Moneyline - Status: OPEN | |
| Chicago Bears | +280 |
| Los Angeles Rams | -360 |
| Las Vegas Raiders vs Baltimore Ravens | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |