Draft misses and a lack of QB pressure and run stopping have made the Lions defense porous and ineffective.
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| Tampa Bay Buccaneers vs Dallas Cowboys | |
| Type: Point Spread - Status: OPEN | |
| Tampa Bay Buccaneers | -115 |
| Dallas Cowboys | -105 |
| Buffalo Bills vs Pittsburgh Steelers | |
| Type: Total - Status: OPEN | |
| Under - 2Q | |
| Over - 2Q | |
| New York Giants vs Denver Broncos | |
| Type: Point Spread - Status: OPEN | |
| New York Giants | -110 |
| Denver Broncos | -110 |
| Indianapolis Colts vs Seattle Seahawks | |
| Type: Point Spread - Status: OPEN | |
| Indianapolis Colts | +105 |
| Seattle Seahawks | -125 |
| Tennessee Titans vs Arizona Cardinals | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Washington Football Team vs Los Angeles Chargers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Carolina Panthers vs New York Jets | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Detroit Lions vs San Francisco 49ers | |
| Type: Moneyline - Status: OPEN | |
| Detroit Lions | +300 |
| San Francisco 49ers | -400 |
| Atlanta Falcons vs Philadelphia Eagles | |
| Type: Point Spread - Status: OPEN | |
| Atlanta Falcons | -110 |
| Philadelphia Eagles | -110 |
| Cincinnati Bengals vs Minnesota Vikings | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Houston Texans vs Jacksonville Jaguars | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| New England Patriots vs Miami Dolphins | |
| Type: Point Spread - Status: OPEN | |
| New England Patriots | -110 |
| Miami Dolphins | -110 |
| Kansas City Chiefs vs Cleveland Browns | |
| Type: Point Spread - Status: OPEN | |
| Kansas City Chiefs | -110 |
| Cleveland Browns | -110 |
| Los Angeles Rams vs Chicago Bears | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Las Vegas Raiders vs Baltimore Ravens | |
| Type: Point Spread - Status: OPEN | |
| Las Vegas Raiders | -105 |
| Baltimore Ravens | -115 |