The Chiefs, who script their first 15 plays, led the NFL during the regular season with nine first-possession touchdowns.
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| Jacksonville Jaguars vs Las Vegas Raiders | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +100 |
| Las Vegas Raiders | -120 |
| Los Angeles Rams vs Buffalo Bills | |
| Type: Moneyline - Status: OPEN | |
| Buffalo Bills | -105 |
| Los Angeles Rams | -115 |
| Atlanta Falcons vs New Orleans Saints | |
| Type: Moneyline - Status: OPEN | |
| New Orleans Saints | -200 |
| Atlanta Falcons | +170 |
| New York Jets vs Baltimore Ravens | |
| Type: Moneyline - Status: OPEN | |
| Baltimore Ravens | -210 |
| New York Jets | +175 |
| Cincinnati Bengals vs Pittsburgh Steelers | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Steelers | +220 |
| Cincinnati Bengals | -270 |
| Miami Dolphins vs New England Patriots | |
| Type: Moneyline - Status: OPEN | |
| New England Patriots | +135 |
| Miami Dolphins | -160 |
| Chicago Bears vs San Francisco 49ers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco 49ers | -280 |
| Chicago Bears | +230 |
| Detroit Lions vs Philadelphia Eagles | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Eagles | -195 |
| Detroit Lions | +165 |
| Carolina Panthers vs Cleveland Browns | |
| Type: Moneyline - Status: OPEN | |
| Cleveland Browns | -210 |
| Carolina Panthers | +175 |
| Houston Texans vs Indianapolis Colts | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Colts | -380 |
| Houston Texans | +290 |
| Washington Commanders vs Jacksonville Jaguars | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +165 |
| Washington Commanders | -195 |
| Tennessee Titans vs New York Giants | |
| Type: Moneyline - Status: OPEN | |
| New York Giants | +250 |
| Tennessee Titans | -300 |
| Arizona Cardinals vs Kansas City Chiefs | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Chiefs | -160 |
| Arizona Cardinals | +135 |
| Minnesota Vikings vs Green Bay Packers | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers | -125 |
| Minnesota Vikings | +105 |
| Los Angeles Chargers vs Las Vegas Raiders | |
| Type: Moneyline - Status: OPEN | |
| Las Vegas Raiders | +160 |
| Los Angeles Chargers | -185 |
| Dallas Cowboys vs Tampa Bay Buccaneers | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Buccaneers | -135 |
| Dallas Cowboys | +115 |
| Seattle Seahawks vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Denver Broncos | -195 |
| Seattle Seahawks | +165 |
| Kansas City Chiefs vs Los Angeles Chargers | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Chargers | +140 |
| Kansas City Chiefs | -165 |
| New Orleans Saints vs Minnesota Vikings | |
| Type: Moneyline - Status: OPEN | |
| Green Bay Packers vs New York Giants | |
| Type: Point Spread - Status: OPEN | |
| Green Bay Packers | -110 |
| New York Giants | -110 |
| Jacksonville Jaguars vs Denver Broncos | |
| Type: Moneyline - Status: OPEN | |
| Jacksonville Jaguars | +230 |
| Denver Broncos | -280 |
| Tampa Bay Buccaneers vs Seattle Seahawks | |
| Type: Point Spread - Status: OPEN | |
| Seattle Seahawks | -110 |
| Tampa Bay Buccaneers | -110 |
| Arizona Cardinals vs San Francisco 49ers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco 49ers | -130 |
| Arizona Cardinals | +110 |
| Los Angeles Rams vs Denver Broncos | |
| Type: Point Spread - Status: OPEN | |
| Los Angeles Rams | -105 |
| Denver Broncos | -115 |