The Chargers might have moved from San Diego to Los Angeles, but they still get to face the Denver Broncos twice each season. The first meeting comes in the second half of the Monday Night Football double-header. The line is Broncos -3.5, meaning Vegas thinks Denver will win by 3.5 points, down a half-point
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| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -120 |
| Green Bay Packers | +100 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |