More so than the first two offseasons of the Kyle Shanahan/John Lynch regime in San Francisco, the 49ers set out to add long-term options in free agency. It started almost immediately with the team agreeing to sign former Tampa Bay Buccaneers Pro Bowl linebacker Kwon Alexander to a four-year, $54 million
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| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |
| Philadelphia Eagles vs Green Bay Packers | |
| Type: Moneyline – Status: OPEN | |
| Philadelphia Eagles | -120 |
| Green Bay Packers | +100 |
| NFC Conference vs AFC Conference | |
| Type: Moneyline – Status: OPEN | |
| AFC Conference | -130 |
| NFC Conference | +100 |